RAF Typhoon jets have joined forces with French warplanes in a combined operation targeting an hidden munitions depot in Syrian territory operated by the Daesh militant organization, per a report from the UK's MoD.
The site, located using intelligence, was assessed as containing munitions and bombs, the announcement noted, and was situated in mountains just to the north of Palmyra in the heart of Syria.
"Our fighter planes employed precision-guided Paveway IV munitions to target a series of access tunnels providing entry to the facility... early reports indicate the objective was successfully hit," the MoD said.
There was no indication of any civilian casualties in the strike late on Saturday and each participating jet made a safe return, the MoD added.
The Typhoon FGR4s were backed up by a Voyager tanker plane.
IS - alternatively referred to as ISIS - established jihadist rule over parts of Iraq and Syria until 2019.
"This strike underscores British leadership, and commitment to operate in unison with our allies, to stamp out any resurgence of IS and their harmful and extremist ideologies in the Middle East," UK Defence Secretary John Healey said.
RAF aircraft have carried out overwatch operations over Syrian airspace to "deter any efforts to regroup" of the group following its routing at the Baghuz confrontation in the year 2019, the MoD reported.
"I extend gratitude to all the members of the UK armed forces participating in this operation for their skill and their bravery," the Defence Secretary said. "They were part of thousands of UK service members on duty over Christmas and New Year. This operation, to eliminate dangerous terrorists who threaten our safety, shows how UK forces are ready to step up, throughout the year, keeping Britain secure at home and influential overseas."
In December, the United States armed forces conducted what it described as a "large-scale strike" targeting IS targets in Syria, following an assault killed two US servicemembers and a local interpreter in the Palmyra area.
The United Nations estimates Islamic State still maintains an estimated 5,000 to 7,000 fighters in both countries.